Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
ccr5_human 17 N-term S => Ter stop gained 0.0001551 18 116046 0 None None
ccr5_human 20 N-term C => Ter stop gained 8.443e-06 1 118448 0 None None
ccr5_human 23 1.25x25 TM1 I => AsnfsTer44 frameshift 8.431e-06 1 118612 0 None None
ccr5_human 22 1.24x24 TM1 K => Ter stop gained 8.396e-06 1 119108 0 None None LB (Van der Waals, polar (charge-assisted hydrogen bond), polar (hydrogen bond with backbone))
ccr5_human 50 1.52x52 TM1 L => ArgfsTer6 frameshift 1.647e-05 2 121404 0 None None
ccr5_human 86 2.60x60 TM2 W => Ter stop gained 8.237e-06 1 121400 0 None None LB (hydrophobic, Van der Waals, aromatic (face-to-face), polar (hydrogen bond))
ccr5_human 101 3.25x25 TM3 C => Ter stop gained 0.0005848 71 121408 0 None None
ccr5_human 104 3.28x28 TM3 L => AspfsTer22 frameshift 8.237e-06 1 121408 0 None None
ccr5_human 184 ECL2 Y => Ter stop gained 9.319e-06 1 107308 0 None None
ccr5_human 186 5.30x31 TM5 Q => Ter stop gained 8.979e-06 1 111374 0 None None
ccr5_human 225 ICL3 R => Ter stop gained 0.0001815 22 121242 1 None None
ccr5_human 261 6.61x61 TM6 Q => Ter stop gained 1.648e-05 2 121386 0 None None LB (Van der Waals, polar (hydrogen bond))
ccr5_human 295 7.51x51 TM7 I => SerfsTer15 frameshift 4.951e-05 6 121194 0 None None
ccr5_human 299 7.55x55 TM7 F => LeufsTer11 frameshift 0.0008167 99 121220 0 None None GP (contact)
ccr5_human 341 C-term R => Ter stop gained 3.515e-05 4 113804 0 None None
ccr5_human 5 N-term V => M missense 8.958e-06 1 111632 0 0.16 0.004
ccr5_human 5 N-term V => G missense 8.956e-06 1 111652 0 0.36 0.001
ccr5_human 11 N-term D => G missense 1.763e-05 2 113430 0 0.05 0.013
ccr5_human 12 N-term I => V missense 8.79e-06 1 113760 0 0.13 0.002
ccr5_human 12 N-term I => T missense 8.783e-06 1 113860 0 0.18 0.004
ccr5_human 13 N-term N => D missense 8.759e-06 1 114168 0 1.0 0.0
ccr5_human 15 N-term Y => H missense 6.09e-05 7 114950 0 0.5 0.0 PTM (Sulfation)
ccr5_human 15 N-term Y => C missense 8.69e-06 1 115076 0 0.16 0.037 PTM (Sulfation)
ccr5_human 17 N-term S => L missense 3.447e-05 4 116046 0 0.17 0.014
ccr5_human 17 N-term S => W missense 2.585e-05 3 116046 0 0.05 0.858
ccr5_human 18 N-term E => K missense 6.848e-05 8 116818 0 0.56 0.104
ccr5_human 20 N-term C => S missense 0.0004234 50 118092 0 0.01 0.994
ccr5_human 22 1.24x24 TM1 K => T missense 1.678e-05 2 119202 0 0.03 0.613 LB (Van der Waals, polar (charge-assisted hydrogen bond), polar (hydrogen bond with backbone))
ccr5_human 25 1.27x27 TM1 V => E missense 1.666e-05 2 120016 0 0.13 0.103 LB (Van der Waals)
ccr5_human 26 1.28x28 TM1 K => R missense 0.0001164 14 120262 0 0.58 0.003 LB (Van der Waals, polar (charge-assisted hydrogen bond))
ccr5_human 29 1.31x31 TM1 A => T missense 8.268e-06 1 120952 0 0.05 0.167 LB (hydrophobic, Van der Waals)
ccr5_human 29 1.31x31 TM1 A => S missense 2.48e-05 3 120952 0 0.09 0.023 LB (hydrophobic, Van der Waals)
ccr5_human 31 1.33x33 TM1 R => H missense 0.0001072 13 121246 0 0.6 0.001
ccr5_human 32 1.34x34 TM1 L => F missense 8.244e-06 1 121296 0 1.0 0.016
ccr5_human 35 1.37x37 TM1 P => S missense 8.241e-06 1 121350 0 0.02 0.178
ccr5_human 35 1.37x37 TM1 P => L missense 1.648e-05 2 121346 0 0.07 0.117
ccr5_human 39 1.41x41 TM1 L => P missense 1.648e-05 2 121390 0 0.0 0.946
ccr5_human 46 1.48x48 TM1 V => M missense 0.0002142 26 121400 0 0.07 0.482
ccr5_human 48 1.50x50 TM1 N => S missense 4.942e-05 6 121404 0 0.0 0.996
ccr5_human 49 1.51x51 TM1 M => K missense 8.237e-06 1 121406 0 0.03 0.148
ccr5_human 49 1.51x51 TM1 M => I missense 8.237e-06 1 121400 0 1.0 0.002
ccr5_human 54 1.56x56 TM1 I => T missense 8.237e-06 1 121408 0 0.13 0.077
ccr5_human 55 1.57x57 TM1 L => Q missense 0.01273 1545 121408 11 0.0 1.0
ccr5_human 55 1.57x57 TM1 L => R missense 8.237e-06 1 121408 0 0.0 1.0
ccr5_human 60 12.49x49 ICL1 R => S missense 0.0007249 88 121400 0 0.02 0.297
ccr5_human 63 2.37x37 TM2 S => C missense 0.0008484 103 121404 1 0.01 0.275
ccr5_human 64 2.38x38 TM2 M => I missense 0.0001153 14 121398 0 0.01 0.694
ccr5_human 68 2.42x42 TM2 Y => H missense 3.295e-05 4 121408 0 0.0 0.996
ccr5_human 68 2.42x42 TM2 Y => N missense 8.237e-06 1 121408 0 0.0 0.996
ccr5_human 68 2.42x42 TM2 Y => S missense 2.471e-05 3 121400 0 0.0 0.995
ccr5_human 69 2.43x43 TM2 L => V missense 4.118e-05 5 121404 0 0.01 0.998
ccr5_human 69 2.43x43 TM2 L => P missense 8.237e-06 1 121404 0 0.0 1.0
ccr5_human 71 2.45x45 TM2 N => S missense 3.295e-05 4 121404 0 0.01 0.973
ccr5_human 72 2.46x46 TM2 L => P missense 8.237e-06 1 121404 0 0.0 1.0
ccr5_human 73 2.47x47 TM2 A => V missense 0.0007578 92 121402 1 0.0 0.806
ccr5_human 73 2.47x47 TM2 A => D missense 8.237e-06 1 121402 0 0.0 0.977
ccr5_human 84 2.58x58 TM2 P => S missense 8.237e-06 1 121398 0 0.0 1.0
ccr5_human 87 2.61x61 TM2 A => P missense 8.238e-06 1 121392 0 0.02 0.992
ccr5_human 87 2.61x61 TM2 A => D missense 8.238e-06 1 121390 0 0.01 0.989
ccr5_human 92 2.66x66 TM2 A => T missense 8.238e-06 1 121394 0 0.17 0.003
ccr5_human 93 23.49x49 ECL1 Q => E missense 1.647e-05 2 121400 0 0.61 0.004
ccr5_human 94 23.50x50 ECL1 W => G missense 8.237e-06 1 121404 0 0.0 1.0
ccr5_human 94 23.50x50 ECL1 W => R missense 8.237e-06 1 121404 0 0.0 1.0
ccr5_human 95 23.51x51 ECL1 D => N missense 8.237e-06 1 121404 0 0.02 0.009
ccr5_human 96 23.52x52 ECL1 F => L missense 8.237e-06 1 121406 0 0.07 0.181
ccr5_human 101 3.25x25 TM3 C => Y missense 8.237e-06 1 121408 0 0.0 1.0
ccr5_human 106 3.30x30 TM3 G => R missense 0.0004283 52 121406 0 0.01 0.947
ccr5_human 107 3.31x31 TM3 L => F missense 0.0002059 25 121406 0 0.37 0.077
ccr5_human 108 3.32x32 TM3 Y => H missense 8.237e-06 1 121404 0 0.03 0.998 LB (aromatic (edge-to-face), Van der Waals, hydrophobic)
ccr5_human 108 3.32x32 TM3 Y => C missense 1.647e-05 2 121404 0 0.04 0.999 LB (aromatic (edge-to-face), Van der Waals, hydrophobic)
ccr5_human 109 3.33x33 TM3 F => L missense 8.237e-06 1 121400 0 0.63 0.002 LB (aromatic (face-to-edge), Van der Waals, hydrophobic)
ccr5_human 110 3.34x34 TM3 I => L missense 4.942e-05 6 121404 0 0.58 0.02
ccr5_human 110 3.34x34 TM3 I => T missense 1.647e-05 2 121400 0 0.39 0.02
ccr5_human 111 3.35x35 TM3 G => S missense 8.237e-06 1 121398 0 0.01 0.687
ccr5_human 113 3.37x37 TM3 F => L missense 8.237e-06 1 121398 0 0.01 0.098
ccr5_human 115 3.39x39 TM3 G => R missense 8.237e-06 1 121404 0 0.01 0.99
ccr5_human 118 3.42x42 TM3 F => L missense 8.237e-06 1 121406 0 0.01 0.155
ccr5_human 120 3.44x44 TM3 I => L missense 8.237e-06 1 121406 0 0.04 0.119
ccr5_human 120 3.44x44 TM3 I => V missense 8.237e-06 1 121406 0 0.15 0.074
ccr5_human 120 3.44x44 TM3 I => T missense 1.647e-05 2 121404 0 0.34 0.513
ccr5_human 121 3.45x45 TM3 L => R missense 0.0001153 14 121404 0 0.0 0.995
ccr5_human 123 3.47x47 TM3 T => K missense 8.237e-06 1 121402 0 0.0 0.928
ccr5_human 124 3.48x48 TM3 I => V missense 8.237e-06 1 121408 0 0.18 0.03
ccr5_human 125 3.49x49 TM3 D => N missense 1.647e-05 2 121404 0 0.0 0.945 SodiumPocket MicroSwitch
ccr5_human 125 3.49x49 TM3 D => E missense 8.237e-06 1 121400 0 0.02 0.996 SodiumPocket MicroSwitch
ccr5_human 128 3.52x52 TM3 L => M missense 8.237e-06 1 121404 0 0.01 1.0
ccr5_human 131 3.55x55 TM3 V => I missense 9.061e-05 11 121402 0 0.0 1.0 GP (contact)
ccr5_human 131 3.55x55 TM3 V => F missense 0.0001812 22 121402 0 0.0 1.0 GP (contact)
ccr5_human 137 34.54x54 ICL2 L => F missense 8.237e-06 1 121404 0 0.02 0.905 GP (contact)
ccr5_human 141 4.38x38 TM4 T => M missense 3.295e-05 4 121392 0 0.0 0.992
ccr5_human 143 4.40x40 TM4 T => N missense 8.238e-06 1 121390 0 0.02 0.033
ccr5_human 144 4.41x41 TM4 F => I missense 8.238e-06 1 121394 0 0.04 0.597
ccr5_human 153 4.50x50 TM4 W => G missense 8.238e-06 1 121384 0 0.01 0.558
ccr5_human 153 4.50x50 TM4 W => C missense 4.119e-05 5 121386 0 0.0 0.816
ccr5_human 159 4.56x56 TM4 A => V missense 8.24e-05 10 121352 0 0.13 0.072
ccr5_human 159 4.56x56 TM4 A => E missense 1.648e-05 2 121352 0 0.0 0.931
ccr5_human 164 4.61x62 TM4 I => T missense 8.242e-06 1 121326 0 0.04 0.078
ccr5_human 164 4.61x62 TM4 I => M missense 1.648e-05 2 121330 0 0.05 0.41
ccr5_human 165 4.62x63 TM4 I => T missense 3.297e-05 4 121330 0 0.02 0.864
ccr5_human 169 ECL2 S => Y missense 8.243e-06 1 121312 0 0.35 0.515
ccr5_human 172 ECL2 E => A missense 6.595e-05 8 121302 0 0.02 0.208
ccr5_human 177 ECL2 T => S missense 8.246e-06 1 121272 0 0.24 0.021
ccr5_human 178 45.50x50 ECL2 C => R missense 4.123e-05 5 121258 0 0.0 0.998 LB (Van der Waals, polar (hydrogen bond with backbone), hydrophobic)
ccr5_human 179 45.51x51 ECL2 S => N missense 8.247e-06 1 121252 0 0.18 0.128 LB (polar (hydrogen bond), Van der Waals)
ccr5_human 180 45.52x52 ECL2 S => F missense 8.248e-06 1 121242 0 0.14 0.003 LB (polar (hydrogen bond with backbone), Van der Waals, polar (hydrogen bond))
ccr5_human 182 ECL2 F => L missense 3.322e-05 4 120414 0 0.08 0.098 LB (hydrophobic, Van der Waals)
ccr5_human 185 ECL2 S => R missense 8.908e-06 1 112262 0 0.18 0.005
ccr5_human 187 5.31x32 TM5 Y => C missense 9.051e-06 1 110482 0 0.17 0.84 LB (polar (hydrogen bond), Van der Waals, hydrophobic)
ccr5_human 189 5.33x34 TM5 F => L missense 8.887e-06 1 112528 0 0.74 0.02
ccr5_human 189 5.33x34 TM5 F => I missense 8.887e-06 1 112528 0 0.49 0.287
ccr5_human 190 5.34x35 TM5 W => R missense 1.84e-05 2 108706 0 0.0 1.0
ccr5_human 190 5.34x35 TM5 W => G missense 9.199e-06 1 108706 0 0.0 1.0
ccr5_human 190 5.34x35 TM5 W => C missense 1.813e-05 2 110322 0 0.0 1.0
ccr5_human 193 5.37x38 TM5 F => L missense 9.06e-06 1 110370 0 0.15 0.019
ccr5_human 206 5.50x50 TM5 P => L missense 8.248e-06 1 121246 0 0.0 1.0 SodiumPocket MicroSwitch
ccr5_human 209 5.53x53 TM5 V => I missense 8.246e-06 1 121270 0 0.61 0.047
ccr5_human 210 5.54x54 TM5 M => I missense 8.245e-06 1 121280 0 0.02 0.936
ccr5_human 216 5.60x60 TM5 G => V missense 4.947e-05 6 121292 0 0.04 0.493
ccr5_human 220 5.64x64 TM5 T => I missense 8.246e-06 1 121272 0 0.26 0.764 GP (contact)
ccr5_human 222 5.66x66 TM5 L => P missense 8.245e-06 1 121284 0 0.01 0.972 GP (contact)
ccr5_human 223 5.67x67 TM5 R => W missense 0.0001155 14 121250 0 0.0 0.967 GP (contact)
ccr5_human 223 5.67x67 TM5 R => Q missense 0.00503 610 121274 15 0.1 0.074 GP (contact)
ccr5_human 225 ICL3 R => Q missense 5.773e-05 7 121252 0 0.06 0.407
ccr5_human 232 6.32x32 TM6 R => G missense 8.244e-06 1 121302 0 0.0 0.673 GP (contact)
ccr5_human 236 6.36x36 TM6 L => I missense 8.243e-06 1 121310 0 0.03 0.927 GP (contact)
ccr5_human 239 6.39x39 TM6 T => N missense 8.242e-06 1 121328 0 0.0 0.629
ccr5_human 240 6.40x40 TM6 I => N missense 8.241e-06 1 121340 0 0.0 0.988 GP (contact)
ccr5_human 243 6.43x43 TM6 V => A missense 8.24e-06 1 121364 0 0.04 0.113
ccr5_human 246 6.46x46 TM6 L => I missense 8.239e-06 1 121370 0 0.29 0.045
ccr5_human 247 6.47x47 TM6 F => S missense 2.472e-05 3 121370 0 0.02 0.997
ccr5_human 248 6.48x48 TM6 W => C missense 8.239e-06 1 121380 0 0.0 0.997 SodiumPocket MicroSwitch LB (hydrophobic, Van der Waals)
ccr5_human 253 6.53x53 TM6 I => T missense 1.648e-05 2 121386 0 0.0 0.939
ccr5_human 253 6.53x53 TM6 I => M missense 8.238e-06 1 121386 0 0.0 0.954
ccr5_human 254 6.54x54 TM6 V => I missense 8.238e-06 1 121386 0 0.06 0.169
ccr5_human 258 6.58x58 TM6 N => S missense 8.238e-06 1 121390 0 1.0 0.004 LB (polar (hydrogen bond), Van der Waals)
ccr5_human 269 7.25x24 TM7 C => Y missense 4.12e-05 5 121352 0 0.0 0.986 LB (hydrophobic, Van der Waals)
ccr5_human 272 7.28x27 TM7 S => P missense 6.594e-05 8 121322 0 0.0 0.864 LB (Van der Waals, polar (hydrogen bond))
ccr5_human 272 7.28x27 TM7 S => C missense 1.649e-05 2 121316 0 0.0 0.159 LB (Van der Waals, polar (hydrogen bond))
ccr5_human 275 7.31x30 TM7 L => W missense 8.244e-06 1 121300 0 0.0 0.999 LB (polar (hydrogen bond), Van der Waals, polar (hydrogen bond with backbone))
ccr5_human 277 7.33x32 TM7 Q => H missense 1.649e-05 2 121270 0 0.11 0.811
ccr5_human 280 7.36x35 TM7 Q => P missense 2.475e-05 3 121232 0 0.0 0.982 LB (Van der Waals, polar (hydrogen bond))
ccr5_human 280 7.36x35 TM7 Q => R missense 8.249e-06 1 121232 0 0.02 0.93 LB (Van der Waals, polar (hydrogen bond))
ccr5_human 281 7.37x36 TM7 V => A missense 3.3e-05 4 121226 0 0.1 0.248
ccr5_human 285 7.41x40 TM7 L => V missense 8.251e-06 1 121194 0 0.1 0.859
ccr5_human 287 7.43x42 TM7 M => K missense 8.251e-06 1 121194 0 0.01 0.098 LB (Van der Waals, polar (charge-assisted hydrogen bond))
ccr5_human 288 7.44x43 TM7 T => A missense 0.000429 52 121198 0 0.09 0.081 SodiumPocket MicroSwitch
ccr5_human 288 7.44x43 TM7 T => M missense 6.604e-05 8 121138 0 0.05 0.298 SodiumPocket MicroSwitch
ccr5_human 289 7.45x45 TM7 H => D missense 2.476e-05 3 121172 0 0.0 1.0
ccr5_human 292 7.48x48 TM7 I => V missense 8.251e-06 1 121192 0 0.83 0.019
ccr5_human 292 7.48x48 TM7 I => S missense 8.252e-06 1 121190 0 0.0 0.817
ccr5_human 293 7.49x49 TM7 N => K missense 8.254e-06 1 121152 0 0.0 0.989 SodiumPocket MicroSwitch
ccr5_human 298 7.54x54 TM7 A => D missense 8.265e-06 1 120996 0 0.0 0.997
ccr5_human 301 8.47x47 H8 G => R missense 8.25e-06 1 121212 0 0.0 0.72 GP (contact)
ccr5_human 318 C-term K => E missense 3.305e-05 4 121034 0 0.28 0.066
ccr5_human 319 C-term R => C missense 0.0001405 17 120982 0 0.2 0.001
ccr5_human 319 C-term R => H missense 4.134e-05 5 120954 0 0.79 0.001
ccr5_human 320 C-term F => V missense 8.27e-06 1 120918 0 0.02 0.067
ccr5_human 328 C-term Q => R missense 8.392e-06 1 119156 0 0.34 0.003
ccr5_human 328 C-term Q => H missense 1.681e-05 2 118986 0 0.54 0.002
ccr5_human 331 C-term A => P missense 8.495e-06 1 117714 0 0.26 0.003
ccr5_human 333 C-term E => K missense 1.713e-05 2 116782 0 0.01 0.013
ccr5_human 333 C-term E => A missense 1.713e-05 2 116752 0 0.01 0.14
ccr5_human 334 C-term R => G missense 1.719e-05 2 116362 0 0.03 0.136
ccr5_human 334 C-term R => Q missense 2.578e-05 3 116386 0 0.03 0.135
ccr5_human 335 C-term A => V missense 0.003535 410 115988 12 0.88 0.001
ccr5_human 335 C-term A => G missense 1.724e-05 2 115988 0 0.22 0.005
ccr5_human 336 C-term S => I missense 6.91e-05 8 115770 0 0.0 0.216 PTM (Phosphorylation (ADRBK2))
ccr5_human 339 C-term Y => F missense 0.001194 137 114706 2 0.17 0.033 PTM (Phosphorylation)
ccr5_human 339 C-term Y => C missense 8.718e-06 1 114706 0 0.02 0.053 PTM (Phosphorylation)
ccr5_human 341 C-term R => Q missense 1.761e-05 2 113582 0 0.48 0.004
ccr5_human 342 C-term S => A missense 8.81e-06 1 113512 0 0.02 0.763 PTM (Phosphorylation (ADRBK2))
ccr5_human 344 C-term G => E missense 7.114e-05 8 112462 0 0.01 0.972
ccr5_human 344 C-term G => V missense 7.114e-05 8 112462 0 0.11 0.931
ccr5_human 344 C-term G => A missense 1.778e-05 2 112462 0 0.21 0.162
ccr5_human 348 C-term I => M missense 1.8e-05 2 111100 0 0.01 0.432


Residue

Diagrams

ICL1 K R L K ICL1ECL1 Q W D F ECL1ICL2 A V F A L K A R ICL2ECL2 R S Q K E G L H Y T C S S H F P Y S ECL2ICL3 R ICL3ECL3 L N ECL3N-term M D Y Q V S S P I Y D I N Y Y T S E P C Q N-termC-term K H I A K R F C K C C S I F Q Q E A P E R A S S V Y T R S T G E Q E I S V G L C-term K I N V K Q I A A R L L P P L Y S L V F I F G F V G N M L V I L I L I N C S M T D I Y L L N L A I S D L F F L L T V P F W A H Y A A A G N T M C Q L L T G L Y F I G F F S G I F F I I L L T I D R Y L A V V H T V T F G V V T S V I T W V V A V F A S L P G I I F T Q Y Q F W K N F Q T L K I V I L G L V L P L L V M V I C Y S G I L K T L L R C N E K K R H R A V R L I F T I M I V Y F L F W A P Y N I V L L L N T F Q E F F G N C S S S N R L D Q A M Q V T E T L G M T H C C I N P I I Y A F V G E K L L V F R N Y F F Q
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